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Uses

INDICATIONS

Chloroquine is indicated for the suppressive treatment and then for acute attacks of malaria because of P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum. The drug is also indicated to the treatments for extraintestinal amebiasis.

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INSTRUCTIONS

Take chloroquine with meals or milk to minimize stomach upset, unless otherwise directed from your doctor.

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t is essential that you just take chloroquine only as directed. Do not take really it, do not take on it more frequently, and do not take on it a bit longer than your doctor ordered. To do so may increase the probability of serious negative effects.

If you adopt chloroquine to keep from getting malaria, keep taking it for that regular of treatment. If you currently have malaria, you ought to still keep taking chloroquine for that fulltime of treatment in case you set out to feel good soon after days. This will help in order to up your infection completely. If you stop taking chloroquine too soon, your symptoms may return.

Chloroquine is ideal if you go on it on the regular schedule. For example, if you are to go on it weekly in order to avoid malaria, it is best to get it on the same day each week. Or if you are to take two doses every day, one dose may be taken with breakfast as well as the other with all the evening meal. Make sure that you tend not to miss any doses. If you've questions about it, check with your overall health care professional.

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If you miss a dose of chloroquine, go as quickly as possible. However, when it is almost time for your upcoming dose, skip the missed dose and return to your regular dosing schedule. Do not double doses.

DOSAGE 

The dosage of chloroquine phosphate is often expressed with regards to equivalent chloroquine base. Each 500 mg tablet of ARALEN offers the equal of 300 mg chloroquine base. In infants and children the dosage is preferably calculated by weight.

Malaria: Suppression - Adult Dose: 500 mg (= 300 mg base) on the identical day of weekly.

Pediatric Dose: The weekly suppressive dosage is 5 mg calculated as base, per kg of weight, but should not exceed the adult dose regardless of weight.

If circumstances permit, suppressive therapy must start a fortnight just before exposure. However, failing this in grown-ups, a primary double (loading) dose of just one g (= 600 mg base), or perhaps in children 10 mg base/kg could possibly be used two divided doses, six hours apart. The suppressive therapy ought to be continued for two months after leaving the endemic area.
For Treatment of Acute Attack.

Adults: An initial dose of just one g (= 600 mg base) followed by a different 500 mg (= 300 mg base) after six to eight hours along with a single dose of 500 mg (= 300 mg base) on each of two consecutive days. This represents a complete dose of 2.5 g chloroquine phosphate or 1.5 g base in 3 days.

The dosage for adults of low body mass as well as infants and children must be determined as follows:

First dose: 10 mg base per kg (but not exceeding an individual dose of 600 mg base).

Second dose: (6 hours after first dose) 5 mg base per kg (and not exceeding one particular dose of 300 mg base).

Third dose: (twenty four hours after first dose) 5 mg base per kg.

Fourth dose: (36 hours after first dose) 5 mg base per kg.

For radical cure of vivax and malariae malaria concomitant therapy with the 8-aminoquinoline compound is important.

Extraintestinal Amebiasis: Adults,1 g (600 mg base) daily for two days, as well as 500 mg (300 mg base) daily for about two to three weeks. Treatment is usually combined with an effective intestinal amebicide.

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STORAGE 

Store the medicine in a very closed container at room temperature, faraway from heat, moisture, and direct light. Keep from freezing.

Keep out of your reach of kids.

Do not keep outdated medicine or medicine will no longer needed.

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Side Effects

Along with its needed effects, medicine may cause some negative effects. Although not all of these unwanted side effects may occur, when they happen they might need medical assistance. When chloroquine is used in short durations, unwanted effects are often rare. However, when it can be used for a long time and/or perhaps in high doses, negative effects may occur and could be serious.

Check with your physician immediately if any of these unwanted side effects occur:
Less common

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Blurred vision
alteration of vision
eye pain
loss in vision
Rare
Black, tarry stools
blood in urine or stools
convulsions (seizures)
cough or hoarseness
feeling faint or lightheaded
fever or chills
increased muscle weakness
lower back or side pain
mood or any other mental changes
painful or difficult urination
pinpoint red spots on skin
ringing or buzzing in ears or any decrease of hearing
sore throat
unusual bleeding or bruising
unusual tiredness or weakness
Symptoms of overdose
Drowsiness
headache
increased excitability

Note: The negative effects within the Less Common category above may also occur or worsen when you stop taking chloroquine.

Some side effects may occur very often do not need medical help. These side effects may go away during treatment since your body adjusts towards the medicine. Also, your wellbeing care professional may be able to let you know about ways to avoid or reduce many of these negative effects. Check with your wellbeing care professional if the following unwanted effects continue or are bothersome or if you've got any queries about them:

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More common


Diarrhea
difficulty in seeing to read
headache
itching (more widespread in black patients)
loss of appetite
nausea or vomiting
stomach cramps or pain
Less common
Bleaching of hair or increased hair loss
blue-black discoloration of skin, fingernails, or inside of mouth
skin rash

Other unwanted side effects not listed could also occur in some patients. If you notice every other effects, talk with your medical practioner.

Precautions

If you'll be taking chloroquine for a long time, it is vital that a medical expert check you at regular visits for any blood problems or muscle weakness that might be a result of chloroquine. In addition, talk with your medical professional immediately if blurred vision, difficulty in reading, or another change in vision occurs during or after treatment. Your doctor might prefer you to have your vision checked by an ophthalmologist (eye doctor).

If your symptoms do not improve inside a couple of days or if they become worse, seek advice from your doctor.

Make sure you are aware how you reply to chloroquine prior to deciding to drive, use machines, or do anything whatsoever else that might be dangerous if you're not able to see well.

Chloroquine may cause blurred vision, difficulty in reading, or other difference in vision. It could also cause some people to get lightheaded.

If these reactions are especially bothersome, talk with a medical expert.

Certain medicines should not be used at or around the time of eating or eating some types of food since interactions may occur. Using alcohol or tobacco with certain medicines could also cause interactions that occurs. Discuss together with your health care professional the application of your medicine with food, alcohol, or tobacco.

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There aren't adequate and well-controlled studies evaluating the security and efficacy of chloroquine in pregnant women. Usage of chloroquine during pregnancy needs to be avoided except inside the suppression or treatments for malaria when inside judgment in the physician the power outweighs the possibility risk to the fetus.

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