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Precautions

Do NOT use Duetact if:

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• you are allergic to the ingredient in Duetact
• you might have moderate to severe heart failure, liver problems or abnormal liver function tests, certain severe problems related to diabetes (eg, diabetic ketoacidosis, diabetic coma), moderate to severe burns, or very high blood acid levels (acidosis)

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• you have type 1 diabetes
• you take bosentan.

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Contact your medical professional or health care provider right away if any of these sign up for you.

Some medical ailments may communicate with Duetact. Tell your physician or pharmacist when you have any medical ailments, particularly if any of the following apply to you:

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• if you happen to be pregnant, likely to get pregnant, or are breast-feeding

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• in the event you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• for those who have allergies to medicines, foods, and other substances

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• if you have had an extreme hypersensitive reaction (eg, severe rash, hives, breathing difficulties, dizziness) to the other sulfonamide medicine like acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glipizide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide

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• when you have a good reputation for kidney, thyroid, heart, or circulatory problems; anemia, stroke; certain hormonal problems (eg, adrenal or pituitary problems, syndrome of inappropriate secretion of antidiuretic hormone [SIADH]); low blood sodium levels; or 'abnormal' amounts associated with an enzyme called glucose 6-phosphate dehydrogenase (G6PD)

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• when you have stomach or bowel obstruction (eg, stomach or bowel blockage, stomach paralysis), consume alcohol, or experienced poor nutrition
• in case you have inadequate health, a top fever, an extreme infection, severe diarrhea, high blood acid levels, or brain or nerves problems, or have had a severe injury
• in case you have a good reputation for bladder cancer, bone fracture, low calcium intake, or weak bones (eg, osteoporosis)

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• if you have swelling problems (edema) or certain eye problems (macular edema)

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• if you may be having surgery.

Some medicines may connect to Duetact. Tell your medical provider in case you consider every other medicines, especially any in the following:

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• Bosentan because liver problems may occur, as well as the effectiveness of both medicines might be decreased
• Beta-blockers (eg, propranolol) since the probability of low blood sugar levels may be increased. They may also hide certain warning signs of low blood glucose levels and earn it harder to notice

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• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), azole antifungals (eg, miconazole, ketoconazole), chloramphenicol, clarithromycin, clofibrate, disopyramide, fenfluramine, fluoxetine, insulin, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenylbutazone, probenecid, quinolone antibiotics (eg, ciprofloxacin), salicylates (eg, aspirin), and sulfonamides (eg, sulfamethoxazole) for the reason that probability of low blood glucose levels could possibly be increased

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• Calcium channel blockers (eg, diltiazem), corticosteroids (eg, prednisone), decongestants (eg, pseudoephedrine), diazoxide, diuretics (eg, furosemide, hydrochlorothiazide), estrogens, hormonal contraceptives (eg, birth control pills), isoniazid, niacin, phenothiazines (eg, promethazine), phenytoin, rifamycins (eg, rifampin), sympathomimetics (eg, albuterol, epinephrine), or thyroid supplements (eg, levothyroxine) since they may decrease Duetact's effectiveness, resulting in high blood sugar levels
• Gemfibrozil because blood sugar levels could possibly be increased or decreased
• Anticoagulants (eg, warfarin) his or her effectiveness could possibly be decreased or perhaps the risk of their unwanted side effects might be increased by Duetact.

This will not be an entire listing of all interactions that may occur. Ask your medical provider if Duetact may communicate with other medicines that you simply take. Check with your doctor before starting, stop, or affect the dose of any medicine.

Important safety information:

• Duetact could potentially cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects could be worse should you get it with alcohol or certain medicines. Use Duetact with caution. Do not drive or perform other possible unsafe tasks and soon you discover how you reply to it.

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• Do not consume alcohol while you take Duetact; it might improve the probability of low blood sugar levels. Rarely, alcohol may connect to Duetact and create a serious reaction with symptoms for example flushing, nausea, vomiting, dizziness, or stomach pain. Discuss any questions or concerns using your doctor.

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• Carry an ID card constantly that says you might have diabetes.
• Proper exercise and dieting are important to be able to shed weight whilst rid of it. Follow the diet and exercise program provided to you through your health care provider.

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• Check your blood sugar levels levels as directed because of your doctor. If they are often higher or less than they will be so you take Duetact exactly as prescribed, tell a medical expert.
• It may be harder to manipulate your blood glucose levels in times of stress like fever, infection, injury, or surgery. Talk along with your doctor about how precisely to regulate your blood glucose if any of these occur. Do not customize the dose of your medicine without checking using your doctor.
• Do not take over the recommended dose without checking with your doctor.
• Duetact could potentially cause low blood glucose levels levels. Low blood glucose could make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also help make your heartbeat faster; you could make your vision change; give you a headache, chills, or tremors; or allow you to more hungry. It is a good option to transport a trusted supply of glucose (eg, tablets or gel) to deal with low blood sugar. If this is not available, you ought to eat or drink a simple supply of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise the blood glucose level quickly. Tell your medical professional right away if this happens. To prevent low blood glucose, eat meals concurrently on a daily basis and do not skip meals.

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• Risk of low blood glucose levels may be increased by severe or prolonged exercise, drinking alcohol, or skipping meals.

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• Duetact posesses a sulfonylurea. It may increase the risk of death from heart problems. Talk together with your doctor about the benefits and perils of this or any other therapies to take care of your condition.

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• Duetact could cause ovulation ladies who have not reached menopause but do not ovulate. To avoid pregnancy, be sure to use effective birth control while using Duetact.
• Duetact might cause you to become sunburned quicker. Avoid the sun, sunlamps, or tanning booths before you discover how you answer Duetact. Use a sunscreen or wear protective clothing if you has to be outside for a lot more than a limited time.

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• Tell your medical professional or dentist which you take Duetact when you get any medical or dentistry, emergency care, or surgery.

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• Duetact could possibly be linked to an increased likelihood of bladder cancer. Discuss questions or concerns together with your doctor.

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• An increased incidence of bone fracture has been reported ladies having Duetact. Tell your medical professional if you have a good bone fracture, low calcium intake, or weak bones (eg, osteoporosis). Tell your physician straight away should you experience any unusual bone pain.

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• Lab tests, including fasting blood glucose levels, hemoglobin A_1c, liver function, and eye exams, could possibly be performed whilst you use Duetact. These tests might be used to monitor your problem or search for negative effects. Be sure to keep all doctor and lab appointments.

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• Use Duetact with caution within the elderly; they could possibly be more responsive to its effects, especially the probability of heart related illnesses or low blood sugar levels.

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• Duetact shouldn't be utilized in children; safety and effectiveness in kids weren't confirmed.

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• Pregnancy and breast-feeding: Duetact may cause injury to the fetus or newborn. If you think you might be pregnant, get hold of your doctor. You will need to discuss the huge benefits and perils of using Duetact while you happen to be pregnant. It is not known if Duetact is found in breast milk. Do not breastfeed while taking Duetact.

When useful for extended periods of time Duetact may not work as well. If your blood glucose levels continues to be in order and then becomes tough to manage, contact your doctor. Do not customize the dose of your medicine without checking together with your doctor.

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