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ARAVA is indicated in adults to the management of active rheumatoid arthritis symptoms (RA):

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Take this medicine only as directed by your doctor. Do not take much more of it, do not take it often, and do not take it for a longer period than your physician ordered.

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The dose with this medicine will be different for different patients. Follow a medical expert's orders or perhaps the directions about the label. The following information includes exactly the average doses with this medicine. If your dose differs, don't change it out unless your physician informs you to do this.

The level of medicine that you simply take depends on the strength in the medicine. Also, the quantity of doses you take every day, the time allowed between doses, along with the length of time you are taking the medicine depend on the problem for which you are utilizing the medicine.

For oral dosage form (tablets):

For rheumatism:

If you miss a dose with this medicine, get it as soon as possible. However, if it's almost time for your next dose, skip the missed dose and go back to your family dosing schedule. Do not double doses.

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Store at 25°C (77°F); excursions permitted 15-30°C (59-86°F). Protect from light. Keep out from the reach of kids. Do not keep outdated medicine or medicine no longer needed. Store the medicine in a very closed container at room temperature, from heat, moisture.

 Keep out from the reach of youngsters. Do not keep outdated medicine or medicine no longer needed. Store the medicine in a closed container at room temperature, far from heat, moisture.


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Side Effects

Stop by using this medicine and look with your medical professional immediately should you be having burning, numbness, tingling, or painful sensations inside the arms, hands, legs, or feet. These could be the signs of a condition called peripheral neuropathy.

Adverse reactions associated with the usage of leflunomide in RA include diarrhea, elevated liver enzymes (ALT and AST), alopecia and rash.

Along with its needed effects, medication could cause some negative effects. Although not these side effects may occur, when they happen they could need medical help.

Check with your physician immediately if any from the following unwanted side effects occur:
More common
Bloody or cloudy urine
difficult or painful breathing
difficult, burning, or painful urination
frequent urge to urinate
loss of appetite
nausea or vomiting
sore throat
tightness inside the chest
yellow eyes or skin
Less common
Burning feeling inside the chest or stomach
burning, prickling, or tingling sensation in the fingers or toes
chest pain
fast heartbeat
joint or muscle pain or stiffness
pounding heartbeat
severe stomach pain
difficulty breathing
tenderness in the stomach area
unusual tiredness or weakness
Incidence mysterious
Area rash
black or tarry stools
bleeding gums
blistering, peeling, or loosening from the skin
blood inside the stools
burning, numbness, tingling, or painful sensations
clay-colored stools
continuing vomiting
cough or hoarseness
dark urine
fever with or without chills
general a feeling of tiredness or weakness
high fever
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
light-colored stools
small of the back or side pain
pains inside the stomach, side, or abdomen, possibly radiating towards the back
pale skin
pinpoint red spots around the skin
rapid, shallow breathing
red wounds, often using a purple center
red, irritated eyes
sores, ulcers, or white spots inside mouth or for the lips
swollen glands
unexplained bleeding or bruising
unpleasant breath odor
unsteadiness or awkwardness
unusual bleeding or bruising
upper right abdominal or stomach pain
vomiting of blood
weakness within the arms, hands, legs, or feet

Some negative effects may occur that always tend not to need medical help. These side effects might go away during treatment because your body adjusts for the medicine. Also, your health care professional may be able to inform you of ways to prevent or reduce a few of these unwanted side effects. Check together with your health care professional if any in the following negative effects continue or are bothersome or if you've any questions about them:
More common
Back pain
hair loss
skin rash
stomach pain
weight loss (unexplained)
Less common
decreased appetite
dry mouth
irritation or soreness in the mouth
itching of the skin
pain or burning inside the throat
runny nose

Other unwanted side effects unpublished might also happen in some patients. If you notice some other effects, check with your medical practioner.

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It is critical that your physician look at progress at regular visits to ensure that this prescription medication is functional. Blood tests are usually necesary to test for negative effects.

Using this medicine while you are pregnant may damage your developing fetus. Use an effective form of birth control to help keep from conceiving. If you think you have conceive with the medicine, tell your doctor immediately.

Leflunomide might also cause birth defects when the father is utilizing it when his sexual partner becomes pregnant. Men taking leflunomide should use condoms as a type of contraceptive during intercourse. A man intending to father a young child should stop taking this medicine and check along with his doctor without delay.

Serious skin reactions can happen using this type of medicine. Stop using this medicine and appearance with a medical expert right away if you've any of the following symptoms while investing in this medicine: blistering, peeling, or loosening from the skin; chills; itching; joint or muscle pain; red lesions on the skin, often using a purple center; sores, ulcers, or white spots inside mouth or around the lips; or unusual tiredness or weakness.

Liver problems may occur while you are utilizing this medicine. Stop employing this medicine and appearance with your physician without delay if you are having more than one of those symptoms: abdominal or stomach pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; decrease of appetite; nausea / vomiting; skin rash; swelling with the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

Leflunomide can temporarily lower the number of white blood cells inside your blood, enhancing the chance of getting infection. It can also lower the amount of platelets, which can be necessary for proper blood clotting. If this occurs, a number of precautions it is possible to take, specially when your blood count is low, to lessen the potential risk of infection or bleeding:

Check with a medical expert right away if you have a cough with or without temperature, shortness of breath, or any issue with breathing.

You needs to have a skin test for tuberculosis before you begin employing this medicine. Tell a medical expert if you or anyone within your home has ever had an optimistic a reaction to a tuberculosis test.

Using this medicine may increase your risk of getting serious infections or cancer. Talk to your doctor if you have concerns relating to this risk.

Do not take other medicines unless to remain discussed with your medical professional. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or nutritional vitamin supplements.

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