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Baclofen can be used for treating spasm of skeletal muscles that induce muscle clonus, rigidity, and pain due to multiple sclerosis. Baclofen relaxes skeletal muscles, the muscles that move the skeleton (otherwise known as striated muscle). Chemically, Baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter in the brain. Neurotransmitters are chemicals that nerves use to talk collectively. GABA released by some nerves causes the game of other nerves to decrease. It is believed that Baclofen, acting like GABA, blocks the experience of nerves within the part of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was approved by the FDA in November, 1977.

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The usual starting dose of Baclofen for adults is 5 mg three times daily. Based on the response, the dose may be increased gradually every 3 days to some maximum of 80 mg/day in many doses.

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Baclofen should be stored between 15°C (59°F) and 30°C (86°F). Keep Baclofen out of the reach of kids.

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Baclofen might cause drowsiness, weakness, dizziness, headache, seizures, nausea, vomiting, low blood pressure levels, constipation, confusion, respiratory depression, inability to sleep, and increased urinary frequency or urinary retention.

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Abrupt discontinuation of oral Baclofen may cause seizures and hallucinations. Abrupt discontinuation of intrathecal Baclofen may result in high fever, rebound spasticity, muscle rigidity, and rhabdomyolysis (muscle breakdown).

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Use of Baclofen with other drugs that also depress the function of nerves can result in additional decrease in brain function.

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In addition towards the risk of depressing brain function, the use of Baclofen and tricyclic antidepressants (e.g., Elavil, Sinequan) together could cause muscle weakness.

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Use of Baclofen and monoamine oxidase inhibitors (e.g. Nardil, Parnate) can result in greater depression of brain function along with low blood pressure.

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As Baclofen can increase blood sugar levels, doses of antidiabetic drugs should be adjusted when Baclofen is taken.

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The use of Baclofen by pregnant women has not been evaluated.

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Baclofen can be detected inside breast milk of mothers taking oral Baclofen. No details are on the use of Baclofen inside the breast milk of mothers receiving Baclofen intrathecally.

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