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INDICATIONS

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Detrol is indicated for your treating overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.

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INSTRUCTIONS

Take Detrol just as prescribed because of your doctor. Do not take in larger or smaller amounts or for more than recommended. Follow the directions on your prescription label.

Your doctor may occasionally make positive changes to dose to ensure that you get the best results.

Take Detrol with water. Do not crush, chew, break, or open a controlled-release capsule. Swallow it whole. Breaking or opening the pill could potentially cause too much of the drug to be removed at one time.

Store Detrol at room temperature far from moisture and heat.

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If you missed a dose - take the missed dose whenever you remember. Skip the missed dose whether it is almost time for your upcoming scheduled dose. Do not take extra medicine to generate in the missed dose.

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DOSAGE

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The recommended dose of Detrol Capsules is 4 mg once daily with water and swallowed whole. The dose could possibly be lowered to 2 mg daily according to individual response and tolerability; however, limited efficacy data are around for Detrol 2 mg.

For patients with mild to moderate hepatic impairment (Child-Pugh Class A or B) or severe renal impairment (CCr 10-30 mL/min), the recommended dose of Detrol is 2 mg once daily. Detrol is not suitable for utilization in patients with severe hepatic impairment (Child-Pugh Class C). Patients with CCKlO mL/min weren't studied and use of Detrol in this population is just not recommended.

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For patients that are taking drugs which can be potent inhibitors of CYP3A4 [e.g., ketoconazole, clarithromycin, ritonavir], the recommended dose of Detrol is 2 mg once daily.

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STORAGE

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Store Detrol at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store from heat, moisture, and lightweight. Do not store within the bathroom. Keep Detrol from the reach of kids and faraway from pets.

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Side Effects

Get emergency medical help when you have these warning signs of an allergic reaction to Detrol: hives; breathlessness; swelling of one's face, lips, tongue, or throat. Stop using Detrol and call a medical expert simultaneously in case you have any of these serious side effects:

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Less serious Detrol negative effects can include:

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This isn't a complete set of unwanted side effects and others may occur. Call your doctor for health advice about unwanted side effects.

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Precautions

Before taking tolterodine, tell a medical expert or pharmacist if you are allergic into it; or in case you have some other allergies. This product may contain inactive ingredients, that may cause allergies or another problems. Talk to your pharmacist for more details.

This medication should not be used when you have certain health conditions. Before applying this medicine, consult your medical professional or pharmacist in case you have: problems emptying your bladder (urinary retention), severe blockage of stomach/intestines (gastric retention), a particular eye condition (uncontrolled narrow-angle glaucoma).

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Before applying this medication, tell your doctor or pharmacist your history, especially of: other bladder problems (e.g., bladder outflow obstruction), stomach/intestinal disease (e.g., ulcerative colitis), slowed movement of stomach/intestines, severe constipation, controlled narrow-angle glaucoma, kidney disease, liver disease, enlarged prostate, a certain muscle disease (myasthenia gravis).

Tolterodine may cause a complaint that affects the heart rhythm (QT prolongation). QT prolongation can infrequently cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that want immediate medical assistance. The likelihood of QT prolongation could possibly be increased for those who have certain health conditions or are taking other drugs that could affect the center rhythm (see also Drug Interactions section). Before using tolterodine, tell your physician or pharmacist in case you have any of the following conditions: certain heart related illnesses (heart failure, slow heartbeat, QT prolongation in the EKG), genealogy of certain heart related illnesses (QT prolongation inside EKG, sudden cardiac death).

Low amounts of potassium or magnesium in the blood may also increase your likelihood of QT prolongation. This risk may increase if you utilize certain drugs (like diuretics/"water pills") or when you have conditions including severe sweating, diarrhea, or vomiting. Talk to your doctor about using tolterodine safely.

This drug could make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or go activity that will require alertness or clear vision until you are sure you are able to perform such activities safely. Limit alcoholic beverages.

This medication could cause decreased sweating. Avoid becoming overheated in hot weather, saunas, or during exercise and other strenuous activities since heatstroke may occur.

Kidney function declines as you age. This medication is removed from the kidneys. Therefore, elderly people may be more responsive to this drug.

This medication should be used only once clearly needed while pregnant. It just isn't known whether Detrol will harm an baby. Tell your physician in case you are pregnant or want to become pregnant while applying this medication. Discuss the potential for loss and benefits with a medical expert.

It is unknown if the drug passes into breast milk. Consult your physician before breast-feeding.

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