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Uses

INDICATIONS

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Indinavir is definitely an antiviral medication inside a number of HIV medicines called protease (PRO-tee-ayz) inhibitors. Indinavir prevents human immunodeficiency virus (HIV) cells from multiplying within your body. It is accustomed to treat HIV, that causes acquired immunodeficiency syndrome (AIDS). Indinavir is just not a cure for HIV or AIDS.

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INSTRUCTIONS

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Take indinavir exactly as it was prescribed to suit your needs. Do not make medication in larger amounts, or take it for more than recommended from your doctor. Follow the directions on your prescription label.

This medication incorporates patient instructions for safe and effective use. Follow these directions carefully. Ask your physician or pharmacist in case you have questions.
Take indinavir with a full glass (8 ounces) of water or skim milk. You can also drink juice, coffee, or tea using this type of medication. Drink at the very least 6 portions of water each day to prevent kidney stones when you are taking indinavir. Indinavir should be taken on a clear stomach, a minimum of 1 hour before or couple of hours after a meal.

If you prefer to go ahead and take medication with food, eat just a light meal, like dry toast with jelly, or corn flakes with skim milk and sugar. Avoid eating a high-fat meal.

It is important to work with indinavir regularly to obtain the most benefit. Get your prescription refilled before you run out of medicine completely.

To make certain prescription drugs is assisting your condition, your blood will have to be tested often. Your liver function could also should be tested. Do not miss any scheduled visits to your doctor.

HIV/AIDS is generally treated having a combination of different drugs. To best treat your trouble, make use of all of one's medications as directed from your doctor. Be sure to see the medication guide or patient instructions provided with each of the medications. Do not make positive changes to doses or medication schedule without advice from your physician. Every person with HIV or AIDS should remain under the proper a physician.

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Take the missed dose whenever you remember and take your following dose on the regularly scheduled time. If you are greater than 120 minutes late in taking your indinavir, skip the missed dose and take the next regularly scheduled dose. Do not take extra medicine to make in the missed dose.

DOSAGE

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Usual Adult Dose for HIV Infection
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.


Usual Adult Dose for Nonoccupational Exposure
800 mg orally every 8 hours or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours.
Duration: Prophylaxis should be initiated as quickly as possible, within 72 hours of exposure, and continued for 28 days.
Indinavir plus ritonavir plus 2 NRTIs is amongst the alternative regimens suited to nonoccupational postexposure HIV prophylaxis.


Usual Adult Dose for Occupational Exposure
800 mg orally every 8 hours 800 mg orally every 8 hours plus lamivudine-zidovudine,
or indinavir 800 mg plus ritonavir 100 mg to 200 mg orally every 12 hours plus lamivudine-zidovudine.
Duration: Therapy has to start promptly, preferably within 1 to 2 hours postexposure. The exact duration of therapy could differ in line with the institution's protocol.

Liver Dose Adjustments
Mild to moderate hepatic insufficiency: 600 mg orally every 8 hours.


Dose Adjustments
Consider reducing the dose to 600 mg every 8 hours if delavirdine, itraconazole, or ketoconazole are administered concomitantly. Increase the dose to 1000 mg every 8 hours if rifabutin is offered concurrently, and decrease the rifabutin dose by half.
Precautions

Strict adherence to the prescribed dose is essential. Patients must not customize the dose or discontinue therapy without talking to their physician.

Adequate hydration (1.5 liters/day) is essential during therapy to cut back the risk of nephrolithiasis. A brief interruption (usually 1 to 3 days) or total discontinuation could possibly be necessary if nephrolithiasis occurs.

Discontinue indinavir if hemolytic anemia occurs. Consider discontinuation if severe leukocyturia develops.

STORAGE

Store indinavir at room temperature faraway from moisture as well as heat. Keep the capsules in their original container, combined with the packet of moisture-absorbing preservative that comes with indinavir capsules.

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Side Effects

Get emergency medical help when you have all of these signs and symptoms of a hypersensitive reaction: hives; difficulty breathing; swelling of one's face, lips, tongue, or throat. Stop taking indinavir and call your medical professional immediately if you have these serious negative effects:

Less serious unwanted effects may include:

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This is not a complete list of negative effects yet others may occur. Tell a medical expert about any unusual or bothersome side effect.

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Precautions

Do not take medicines in case you are allergic to indinavir.
Do not take indinavir with amiodarone (Cordarone, Pacerone), cisapride (Propulsid), pimozide (Orap), alprazolam (Xanax), oral midazolam (Versed), triazolam (Halcion), or ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine). These drugs can cause life-threatening unwanted side effects if you are using them while you are taking indinavir.

Before taking indinavir, tell your physician in case you are allergic to any drugs, or if you have:

If you have all of these conditions, you will need a dose adjustment or special tests to securely take indinavir.
FDA pregnancy category C. This medication could possibly be bad for an child. Tell a medical expert if you're pregnant or want to conceive during treatment. HIV might be passed towards the baby in the event the mother is not properly treated in pregnancy. Take all of the HIV medicines as forwarded to moderate your infection when you are pregnant.

Your name may need to be listed on an antiviral pregnancy registry when you start using medicines.
You should not breast-feed if you are using indinavir. Women with HIV or AIDS should not breast-feed at all. Even if your baby is born without HIV, you might still pass the virus on the baby inside your breast milk.

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